- Platelet Rich Plasma (PRP) Defined
- Blood-Derived Growth Factors
- Growth Factor Production Known Effects
What is Platelet-rich Plasma (PRP)?
Platelet-rich plasma (PRP) is blood plasma that has been enriched with platelets. As a concentrated source of autologous platelets, PRP contains (and releases through degranulation) several different growth factors and other cytokines that stimulate healing of bone and soft tissue.
Blood-Derived Growth Factors
The internal essence of your blood contains life-giving fundamental protein growth factors. PRP utilizes a leading-edge patented technology specifically designed. With a simple, quick and advantageous process, Dr. Michelson is able to derived a high concentration of biological nutrient-rich cells and create autologous platelet-rich plasma.
1. The practitioner draws a similar amount of blood required for a basic lab test.
2. The practitioner places the blood into a centrifuge and spins the blood at a very rapid rate to separate the platelets from the other components of the blood
3. The platelet-rich plasma is activated to release at least 8 essential growth factors and signaling proteins. Platelet-rich plasma is a technology that deploys aspects of blood based biochemistry. Because all constitutes retrieved in PRP are exclusively from the patient (autologous in origin), there is virtually no risk of an allergic reaction or intolerance. Nevertheless, before any treatment, disclose all the medications you are taking (including herbs) with your doctor
Growth Factor Production Known Effects
Epidermal Growth Factor (EGF)
Plays a significant role in the regulation of cell growth, proliferation, and differentiation during the remodeling phase. Stimulates keratinocyte and fibroblast production.
Transforming Growth Factor (TGF)
Promotes angiogenesis which is the physiological process involving the growth of new blood vessels.
Vascular Endothelial Growth Factor (VEGF)
An important signaling protein involved in both vasculogenesis and angiogenesis, the growth of blood vessels from pre-existing vasculature.
Fibroblast Growth Factor (FGF)
Promotes angiogenesis, granulation, and epithelialization for the intricate process of the skin repairing itself after injury.
Platelet-Derived Growth Factor (PDGF)
Attracts macrophages and fibroblasts to the zone of injury. Promotes collagen growth and proteoglycan synthesis. Interleukins, Macrophages, keratinocytes, endothelial cells, lymphocytes, fibroblasts, osteoblasts, basophils, mast cells Activates fibroblast differentiation. Induces collagen and proteoglycan synthesis for healthy cell production and repair of damaged tissues.
Collagen Stimulating Growth Factor
Stimulates granulocyte and macrophage proliferation for the growth of healthy tissue and blood cells.
Keratinocyte Growth Factor (KGF)
Keratinocyte migration, differentiation, and proliferations directly enhance wound healing and the generation of new skin.